◆主要学习和工作经历

●2003年-2006年，中国中医科学院攻读博士学位。

●2002年至今，在中国中医科学院中药研究所（中药资源中心）工作，博士生导师。

●2010年-2014年，中国科学院植物研究所进行博士后研究。

◆主要研究内容

主要研究方向为药用植物萜类活性成分的生物合成途径解析，并利用合成生物学生产特定高附加值的化合物。已系统克隆鉴定了丹参、冬凌草、乌头属及樟科等植物中的二萜及单萜合酶并对其功能进化机制进行了探讨，以第一作者或通讯作者在Nature Communications、ACS Catalysis、Acta Pharm Sin B等杂志发表文章20余篇，授权专利3项。

◆主要研究课题

1. 国家自然基金联合基金：基于免疫细胞互作网络的浙产道地药材浙麦冬抗冠心病作用及其品质形成机制研究（U23A20513），2024-2027

2. 国家重点研发：紫杉醇、雷公藤内酯等天然产物细胞工厂创建及异源合成 子任务（2020YFA0908003） 2020-2025

3. 国家重点研发：植物活性代谢物生物合成的机制研究 子任务（2018YFA0900601） 2019-2024

4. 中国中医科学院科技创新项目：丹参酮I生物合成P450基因的功能研究（CI2021A04109）2021-2024

◆主要研究成果（近5年）

一、代表性论文及论著：

（一）代表性论文（*通讯作者）：

1.Zhang HY，Cai P，Guo J, Gao JQ, Xie LF, Su P, Zhai XX, Jin BL，Cui GH*, Zhou YJ*, Huang LQ*. Engineering cellular dephosphorylation boosts (+)-borneol production in yeast. Acta Pharm Sin B. doi.org/10.1016/j.apsb.2024.12.039

2.Jin BL, Xu KW, Guo J, Ma Y, Yang J, Chen NH, Zeng T, Wang J, Liu JL, Tian M, Ma Q, Zhang HY, Peters RJ, Cui GH*, Wu RB*, Huang LQ*. From Functional Plasticity of Two Diterpene Synthases (IrTPS2/IrKSL3a) to Enzyme Evolution. ACS Catalysis.2024, 14, 5, 2959–2970

3.Xu W Ma Q, Chen T, Zhang HY, Ma GL, Mafu SB, Guo J, Fan XH, Cui GH*, Jin BL*. Functional characterization of seven terpene synthases from Ophiopogon japonicus via engineered Escherichia coli. Science of Traditional Chinese Medicine, 2024;2(4):312–318.

4.Tian M#, Jin BL#, Chen LL, Ma R, Ma Q, Li X, Chen T, Guo J, Ge H, Zhao X, Lai C, Tang JF, Cui GH*, Huang LQ*. Functional diversity of diterpene synthases in Aconitum plants. Plant Physiology and Biochemistry. 2023, 202:107968 

5.Chen LL#, Tian M#, Jin BL, Yin B, Chen T, Guo J, Tang J, Cui GH*, Huang LQ*. Integrating Metabolomics and Transcriptomics to Unveil Atisine Biosynthesis in Aconitum gymnandrum Maxim. International Journal of Molecular Sciences, 2022, 23(21), 13463

6.Wang J#, Mao Y, Ma Y, Yang J, Jin BL, Lin H, Tang JF, Zeng W, Zhao Y, Gao W, Peters RJ, Guo J*, Cui GH*, Huang LQ*. Diterpene synthases from Leonurus japonicus elucidate epoxy-bridge formation of spiro-labdane diterpenoids. Plant Physiol. 2022, 189(1):99-111

7. C, Ling F, Yao Y, Cui GH*, Huang LQ*. Elucidation of the essential oil biosynthetic pathways in Cinnamomum burmannii through identification of six terpene synthases. Plant Sci. 2022, 317:111203.

8.Ma Y#, Cui GH#*, Chen T, Ma XH, Wang RS, Jin BL, Yang J, Kang LP, Tang JF, Lai CJS, Wang YN, Zhao YJ, Shen Y, Zeng W, Peters RJ, Qi XQ*, Guo J*, Huang LQ*. Expansion within the CYP71D subfamily drives the heterocyclization of tanshinones synthesis in Salvia miltiorrhiza. Nature Communication. 2021, 12(1):685

9.Mao LY, Jin BL, Chen LL, Tian M, Ma R, Yin B, Zhang H, Guo J, Tang JF, Chen T, Lai C, Cui GH*, Huang LQ*. Functional identification of the terpene synthase family involved in diterpenoid alkaloids biosynthesis in Aconitum carmichaelii. Acta Pharm Sin B. 2021, 11(10):3310-3321

10.Hu ZM, Liu XY, Tian M，Ma Y, Jin BL, Gao W, Cui GH*, Guo J*, Huang LQ*. Recent progress and new perspectives for diterpenoid biosynthesis in medicinal plants. Medicinal Research Reviews. 2021: 1-27.

11.Ma R, Su P, Guo J, Jin BL, Ma Q, Zhang H, Chen L, Mao L, Tian M, Lai C, Tang J, Cui GH*, Huang LQ*. Bornyl diphosphate synthase from Cinnamomum burmanni and its application for (+)-borneol biosynthesis in Yeast. Front. Bioeng. Biotechnol. 2021, 9: 631863. 

12.Ma R, Su P, Ma Q, Guo J, Chen S, Jin B, Zhang H, Tang J, Zhou T, Xiao C, Cui GH*, Huang LQ*. Identification of (-)-bornyl diphosphate synthase from Blumea balsamifera and its application for (-)-borneol biosynthesis in Saccharomyces cerevisiae. Synthetic and Systems Biotechnology, 2022, 7:490-497.

13.Ma R, Su P, Jin B, Guo J, Tian M, Mao L, Tang J, Chen T, Lai C, Zeng W, Cui GH*, Huang LQ*. Molecular cloning and functional identification of a high-efficiency (+)-borneol dehydrogenase from Cinnamomum camphora (L.) Presl. Plant Physiol Biochem. 2021,158:363-371.

14.Chen LL, Lai CJ, Mao LY, Yin BW, Tian M, Jin BL, Wei XY, Chen JL, Ge H, Zhao X, Li WY, Guo J, Cui GH*, Huang LQ*. Chemical constituents in different parts of seven species of Aconitum based on UHPLC-Q-TOF/MS. J Pharm Biomed Anal. 2021, 30;193:113713. 

15.徐文，田梅，申业，郭娟，靳保龙*. 崔光红*. 丹参转录因子及相关调控蛋白研究进展. 中国中药杂志，2025, 50（1）：58-70

16.马青，马蕊，苏平，申业，陈美兰，靳保龙，欧阳少林，郭娟，崔光红*，黄璐琦*. 樟树化学型形成关键萜类合酶的系统鉴定. 中国中药杂志，2023，48（9）：2307-2315

17.包丽琼，陈同，靳保龙，李奉胜，李佐君，陈美兰，王铁霖，崔光红*，黄璐琦*. 丹参酮类化合物调控丹参根微生物组的研究. 中国中药杂志，2021, 46（11）：2806-2815