副研究员
◆主要学习和工作经历
●2023.06-至今,中国中医科学院中药资源中心,副研究员,硕士生导师;任中国中医科学院中药资源中心分子生药研究室副主任
●2021.08-2023.06,中国中医科学院中药资源中心,助理研究员
●2019.09-2021.06,美国斯克里普斯研究所,博士后,微生物天然产物生物合成(合作导师: Ben Shen教授)
●2016.09-2019.07,中国中医科学院中药资源中心,博士,中药学(导师: 黄璐琦研究员)
●2015.09-2016.09,中国中医科学院中药资源中心,科研助理
●2012.09-2015.07,首都医科大学,硕士,中药学(导师: 黄璐琦研究员)
●2008.09-2012.07,首都医科大学,本科,中药学
◆主要社会兼职
中国中西医结合学会分子生药学专业委员会青年委员
中国药学会中医肿瘤药物与临床研究专业委员会青年委员
◆主要研究内容
主要研究为中药活性成分未知功能酶元件挖掘与功能表征、酶改造与应用、活性成分合成生物学研究,主持国家自然科学基金青年项目、中国科协青年人才托举项目、中国中医科学院优秀青年科技人才培养专项等,在Nature Communications、ACS Catalysis、Horticulture Research、The Plant Journal等期刊发表论文50余篇,参编论著1部,获授权发明专利10余项,担任Horticulture Research、The Plant Journal、Journal of Agricultural and Food Chemistry、《中国中药杂志》等期刊审稿人。
◆主要研究课题
1. 国自然青年科学基金项目:洋地黄毒苷14β羟基活性基团形成相关CYP450羟化酶基因功能研究(82204568),2023-2025
2. 中国科协青年人才托举项目:中药活性成分合成生物学研究(CACM-(2022-QNRC1- 20)),2023-2025
3. 道地药材品质保障与资源持续利用全国重点实验室2023年度科研专项:抗肿瘤活性成分小白菊内酯及其衍生物合成研究(CI2023E002-Y-16),2023-2024
4. 中国中医科学院科技创新工程重点协同攻关项目: 续随子中复杂大环二萜类活性成分合成机制研究及其基因编辑育种(CI2024C004YN),2024-2027
5. 中国中医科学院优秀青年科技人才(创新类)培养专项(ZZ16-YQ-042),2022-2025
◆主要研究成果
一、代表性论文及论著:
(1) 代表性论文(一作或共一#,通讯作者*):
1. Jiadian Wang#, Qin Xie#, Xinmeng Wang, Mengfei Long, Yanying Chen, Zheng Liu, Meng Xia, Juan Guo, Zeping Wang, Rongfeng Wang, Siyu Shen, Yun Lu, Yan Yin, Yating Hu, Wei Gao*, Xiao Zhang*, Ping Su*, Luqi Huang*. Discovery of key cytochrome P450 monooxygenase (C20ox) enables the complete synthesis of tripterifordin and neotripterifordin. ACS Catalysis, 15: 2690-2702 (2025).
2. Hanwen Yu, Haixia Wang, Xiao Liang, Juan Liu, Chao Jiang, Xiulian Chi, Nannan Zhi, Ping Su*, Liangping Zha*, Shuangying Gui*. A telomere-to-telomere gap-free genome assembly provides genetic insight into the triterpenoid saponins biosynthesis in Platycodon grandiflorus. Horticulture Research, uhaf030 (2025).
3. Shuang Liu, Shuo Yang, Ping Su*. Chemo-enzymatic synthesis of bioactive compounds from traditional Chinese medicine and medicinal plants. Science of Traditional Chinese Medicine, 2: 95-103 (2024).
4. Xiaoyu Xu, Meng Xia, Yang Han, Honghu Tan, Yanying Chen, Xinqi Song, Shijun Yuan, Yifeng Zhang, Ping Su*, Luqi Huang*. Highly promiscuous flavonoid di-O-glycosyltransferases from Carthamus tinctorius L. Molecules, 29: 604 (2024).
5. 韩洋, 夏梦, 张逸风, 苏平*, 黄璐琦*. 洋地黄毒苷合成途径3β-羟基类固醇脱氢酶基因克隆及功能分析. 中国中药杂志, 49: 370-378 (2024).
6. 谭洪虎, 夏梦, 苏平*, 黄璐琦*. 瑞香狼毒贝壳杉烷型二萜类合成酶功能表征. 中国中药杂志, 49: 2410-2421 (2024).
7. 谭洪虎, 夏梦, 苏平*, 黄璐琦*. 巴豆烷型活性大环二萜类化合物的研究进展. 中国中药杂志, 48: 4620-4633 (2023).
8. Lichan Tu#,Ping Su#,Zhongren Zhang#,Linhui Gao,Jiadian Wang,Tianyuan Hu,Jiawei Zhou,Yifeng Zhang,Yujun Zhao,Yuan Liu,Yadi Song,Yuru Tong,Yun Lu,Jian Yang,Cao Xu,Meirong Jia,Reuben J. Peters,Luqi Huang*,Wei Gao*. Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis. Nature Communications, 11: 971 (2020).
9. Ping Su,Hongyu Guan,Yujun Zhao,Yuru Tong,Meimei Xu,Yifeng Zhang,Tianyuan Hu,Jian Yang,Qiqing Cheng,Linhui Gao,Yujia Liu,Jiawei Zhou,Reuben J. Peters,Luqi Huang*,Wei Gao*. Identification and functional characterization of diterpene synthases for triptolide biosynthesis from Tripterygium wilfordii. The Plant Journal, 93: 50-65 (2018).
10. Ping Su#, Linhui Gao#, Yuru Tong, Hongyu Guan, Shuang Liu, Yifeng Zhang, Yujun Zhao, Jiadian Wang, Tianyuan Hu, Lichan Tu, Jiawei Zhou, Baowei Ma, Luqi Huang*, Wei Gao*. Analysis of the role of geranylgeranyl diphosphate synthase 8 from Tripterygium wilfordii in diterpenoids biosynthesis. Plant Science 285: 184-192. (2019)
11. Ping Su#, Linhui Gao#, Shuang Liu, Hongyu Guan, Jian Wang, Yifeng Zhang, Yujun Zhao, Tianyuan Hu, Lichan Tu, Jiawei Zhou, Baowei Ma, Xihong Liu, Luqi Huang*, Wei Gao*. Probing the function of protein farnesyltransferase in Tripterygium wilfordii. Plant Cell Reports 38: 211-220. (2019).
12. Rui Ma#,Ping Su#,Qing Ma#,Juan Guo,Suiqing Chen,Baolong Jin,Haiyan Zhang,Jinfu Tang,Tao Zhou,Chenghong Xiao,Guanghong Cui*,Luqi Huang*. Identification of (-)-bornyl diphosphate synthase from Blumea balsamifera and its application for (-)-borneol biosynthesis in Saccharomyces cerevisiae. Synthetic and Systems Biotechnology, 7: 490-497 (2022).
13. Qing Ma#,Rui Ma#,Ping Su#,Baolong Jin,Juan Guo,Jinfu Tang,Tong Chen,Wen Zeng,Changjiangsheng Lai,Fengqing Ling,Yanfei Yao,Guanghong Cui*,Luqi Huang*. Elucidation of the essential oil biosynthetic pathways in Cinnamomum burmannii through identification of six terpene synthases. Plant Science, 317: 111203 (2022).
14. Rui Ma#,Ping Su#,Juan Guo,Baolong Jin,Qing Ma,Haiyan Zhang,Lingli Chen,Liuying Mao,Mei Tian,Changjiangsheng Lai,Jinfu Tang,Guanghong Cui*,Luqi Huang*. Bornyl diphosphate synthase from Cinnamomum burmanni and its application for (+)-borneol biosynthesis in yeast. Frontiers in Bioengineering and Biotechnology, 9: 631863 (2021).
15. Meng Zhang#, Ping Su#, Yongjin Zhou, Xiujuan Wang, Yujun Zhao, Yujia Liu, Yuru Tong, Tianyuan Hu, Wei Gao*, Luqi Huang*. Identification of geranylgeranyl diphosphate synthase genes from Tripterygium wilfordii. Plant Cell Reports 34: 2179-2188. (2015)
16. Ping Su, Qiqing Cheng, Xiujuan Wang, Xiaoqing Cheng, Meng Zhang, Yuru Tong, Fei Li, Wei Gao*, Luqi Huang*. Characterization of eight terpenoids from tissue cultures of the Chinese herbal plant, Tripterygium wilfordii, by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Biomedical Chromatography 28: 1183-1192. (2014)
二、专利:
1. 艾纳香单萜合酶BbTPS3及其相关生物材料与应用,发明人: 黄璐琦、苏平、马蕊、高伟、崔光红,专利号:ZL201910775971.6
2. 龙脑樟冰片脱氢酶CcBDH3及其编码基因与应用,发明人: 黄璐琦、马蕊、苏平、崔光红、郭娟,专利号:ZL201911081616.5
3. 雷公藤细胞色素p450氧化酶在制备松香烷型二萜化合物中的应用,发明人: 高伟、黄璐琦、苏平、屠李婵,专利号:ZL201911086944.4
4. 雷公藤二萜合酶TwCPS1在制备松香烷型二萜化合物中的应用,发明人: 高伟、黄璐琦、苏平、周家伟,专利号:ZL201611144657.0
5. 雷公藤焦磷酸合酶TwCPS4及其制备松香烷型二萜化合物的应用,发明人: 高伟、黄璐琦、苏平、周家伟,专利号:ZL201611142858.7
三、主要获奖情况:
1. 2022年,《药用植物萜类功能基因多元适配性鉴定系统创建及应用》获中华中医药学会科学技术奖二等奖(2/10)
2. 2024年,《中药活性成分的生物合成研究及其示范应用》获中国中西医结合学会科学技术一等奖(3/17)